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The AUC of the active metabolite, N-desmethyl sildenafil, was increased 62% by loop and potassium-sparing diuretics and 102% by nonspecific beta-blockers.
Other adverse reactions occurred at a rate of >2%, but equally common on placebo: respiratory tract infection, back pain , flu syndrome , and arthralgia .
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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.
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Some sildenafil users have complained of blurriness and loss of peripheral vision .
) resulted in a 63% decrease of sildenafil AUC and a 55% decrease in sildenafil Cmax .
jsp © 2001-2007 Pfizer Inc.
Its primary competitors on the market are tadalafil (Cialis), and vardenafil (Levitra).
No significant interactions were shown with tolbutamide (250 mg) or warfarin (40 mg), both of which are metabolized by CYP2C9.
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[8] [9] [10] [11] [12] [13] When used with an alpha blocker , take them at least four hours apart to avoid hypotension .
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Over 550 patients were treated for longer than one year.
There were no severe adverse events potentially related to blood pressure and no episodes of syncope reported in this study.
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At doses above the recommended dose range, adverse events were similar to those detailed above but generally were reported more frequently.
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In these studies, only one patient discontinued due to abnormal vision.
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org/wiki/Sildenafil " Categories : Accuracy disputes | Articles with unsourced statements since February 2007 | All articles with unsourced statements | PDE5 inhibitors | Citrates Views.
Or click the first letter of a drug name: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z AdvancedSearch .
Seek emergency medical attention if you think you have used too much of this medicine.
Multum's drug information does not endorse drugs, diagnose patients or recommend therapy.
Over 550 patients were treated for longer than one year.
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Avoid using other medicines to treat impotence, such as alprostadil (Caverject, Muse, Edex) or yohimbine (Yocon, Yodoxin, others), without first talking to your doctor.
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